Southampton vs Arsenal - Saturday, kick-off 8pm
If Mikel Arteta has spent the international break stewing on Arsenal's Carabao Cup final defeat to Man City, his mood would not have been improved by an increase in injury issues through his squad.
The Gunners are up to double figures when it comes to players sidelined or a doubt with fitness problems ahead of this weekend. While some of those injured players may be able to turn out at Southampton, Arteta will also be wary of how he manages his resources ahead of a Champions League quarter-final first leg at Sporting on Tuesday.
Balancing his squad and selections will be key if Arsenal are to keep a Premier League-Champions League-FA Cup treble bid on track.
Could that all pave the way for 16-year-old Max Dowman to start? St Mary's would be a fitting venue for England's latest teenage prodigy to build on his recent goal for the country's U19s, having been the home ground of Theo Walcott when he made his breakthrough, also aged 16.
Southampton's own selections will also be interesting. They are unbeaten in 14 games and pushing for a Championship play-off place, with a huge game at Wrexham in that battle on Tuesday. How both managers prioritise this tie could be a decisive factor.
Peter Smith
West Ham vs Leeds - Sunday, kick-off 4.30pm
Premier League survival is the priority for West Ham and Leeds, but a morale-boosting victory over a relegation rival for a place in the FA Cup semi-finals cannot be underestimated.
Just four points separate the sides with six games remaining and the pair face each other on the final day in a potential season decider. Sunday's tie provides the opportunity to make a statement before the run-in begins.
West Ham have not reached an FA Cup semi-final since 2006 before they famously lost to Liverpool in one of the competition's great finals. Leeds' wait for a spot in the last four has been even longer. It has been almost 40 years since they made the semi-finals in 1987 and they are already in rare territory making it this far.
Nuno Espirito Santo's Hammers have lost only three times in their last 10 games, to Aston Villa, Liverpool and Chelsea, and will hope winger Crysencio Summerville will return to fitness soon from a calf injury after playing a key part in that run.
Leeds' problems have been at the top end of the pitch recently, failing to score in their last four league matches although they did put three past Norwich City in the previous round.
Following the international break, this tie is about more than just a trip to Wembley with the run-in on the horizon.
David Richardson
